Social enterprises are more likely to be sustainable and successful when venture teams engage in the design of appropriate technologies, develop business plans, and implement solutions with an integrated approach, rather than in a linear, piecemeal fashion. Through our academic ventures over the past decade, we have come to realize that a collaborative and integrated "triple helix" approach of system design, business planning, and implementation strategy development is essential. In terms of venture success, the process of executing the business strategy is as important as the product itself. This integrated design process encompasses conceptualization, validation, design, field-testing, implementation, and evaluation in an iterative process. Through the discussion of several case studies, this paper explores the tenets of implementation strategy development that will inform the conceptualization of a triple helix design process for sustainable and scalable technology ventures, specifically for base of the pyramid contexts.